On April 11, 2019, we released our fourth short video, Futility Stopping . This topic is presented by Dr. Anna McGlothlin of Berry Consultants, LLC. 

When evidence emerges that an ongoing clinical trial is unlikely to meet its objective, a futility rule terminating the trial protects patients and saves resources. Patients are spared potential side effects of a ineffective treatment and may enroll in more promising trials, while sponsors can save 20-50% or more of the cost of going to the maximal sample size. In this short video Dr. Anna McGlothlin will present examples of futility rules, examine the trade-off between sample size savings and power, and illustrate graphical tools for exploring and selecting rules in practice.